Journal: Journal of medicinal chemistry

Article Title: A Fast Method to Monitor Tyrosine Kinase Inhibitor Mechanisms.

doi: 10.1021/acs.jmedchem.4c02042

Figure Lengend Snippet: Figure 4. Met-CH3 1H−13C HMQC correlation spectra of unphosphorylated full-length Src in the absence (blue) and in the presence (red) of dasatininb (A) and eCF506 (B) compared to that of the free KD (black). Natural abundance signals from Src are shown in light gray. The models below show the KDs of the autoinhibited form of Src (PBD 2SRC, brown), the eCF506 complex (PDB 7NG7, pink), and the dasatinib complex (PDB 3G5D, blue). (C) Schematic representation of the M305 peak in the different systems studied in this work. The label’s colors are assigned automatically in a blue to red scale according to the 13C chemical shift. NMR conditions are the same as in Figure 1.

Article Snippet: Temperature was 298 K. Dasatinib (99.88% purity), eCF506 (99.30% purity), ponatinib (99.43% purity), and A419259 (99.75% purity) were purchased from MedChemExpress and used without further purification.

Techniques:

Journal: Chemistry (Weinheim an Der Bergstrasse, Germany)

Article Title: Reactivity of Nickel(II) Porphyrins in oCVD Processes—Polymerisation, Intramolecular Cyclisation and Chlorination

doi: 10.1002/chem.201900793

Figure Lengend Snippet: Cyclic voltammograms of NiDPP in CH 2 Cl 2 /[ n Bu 4 N][PF 6 ] solution.

Article Snippet: X‐band CW EPR spectra were recorded with a Magnettech MS 300 spectrometer and a Hewlett Packard 5340A frequency counter at a microwave frequency of 9.39 GHz in CH 2 Cl 2 solution (298 and 77 K).

Techniques:

Journal: Chemistry (Weinheim an Der Bergstrasse, Germany)

Article Title: Reactivity of Nickel(II) Porphyrins in oCVD Processes—Polymerisation, Intramolecular Cyclisation and Chlorination

doi: 10.1002/chem.201900793

Figure Lengend Snippet: a) EPR spectrum of NiDPP/WCl 6 solution in CH 2 Cl 2 rapidly frozen at 77 K (orange trace) and evolution of the EPR spectrum (normalised) upon thawing the solution and warming to room temperature over time. b) UV/Vis/NIR and MALDI‐HR mass spectrum of the final NiDPP/WCl 6 solution (inset).

Article Snippet: X‐band CW EPR spectra were recorded with a Magnettech MS 300 spectrometer and a Hewlett Packard 5340A frequency counter at a microwave frequency of 9.39 GHz in CH 2 Cl 2 solution (298 and 77 K).

Techniques: